comparison between sterile water &water for injection:
- a- pyrogen free
- b-free from sod. Chloride
- c- Isotonic
- d-free from bacteria
- e- A&C
Both sterile water and water for injection (WFI) are highly purified forms of water that are free of microorganisms and other contaminants. However, there are some key differences between the two.
Sterile water is typically produced by distillation or reverse osmosis, followed by sterilization using a variety of methods such as heat, radiation, or filtration. It is used in a variety of applications, including irrigation, cleaning, and wound care.
WFI is produced using more stringent methods than sterile water, and it is subject to stricter quality control standards. It is typically produced by distillation, followed by reverse osmosis and ultrafiltration. WFI is used in the preparation of parenteral (injectable) drugs and other pharmaceutical products.
Key differences between sterile water and WFI:
|
Characteristic |
Sterile
water |
Water for
injection (WFI) |
|
Purity |
High |
Very high |
|
Microbiological
quality |
Sterile |
Sterile
and apyrogenic (free of pyrogens, which can cause fever and other adverse
reactions) |
|
Production
methods |
Distillation
or reverse osmosis, followed by sterilization |
Distillation,
followed by reverse osmosis and ultrafiltration |
|
Applications |
Irrigation,
cleaning, wound care |
Preparation
of parenteral drugs and other pharmaceutical products |
Which one to use?
The choice of whether to use sterile water or WFI depends on the specific application. For applications where a high level of purity is required, but sterility is not essential, sterile water is a good option. For applications where sterility is essential, such as in the preparation of parenteral drugs, WFI must be used.
It is important to note that both sterile water and WFI should be stored and used in a manner that prevents contamination. This includes using sterile containers and equipment, and following proper aseptic technique.
Labels
Pharmacy