Differences between captopril and other ACE inhibitors:
- a- Differ in potency, (captopril is more potent than other ACE inhibitors)***
- b- Mode of action.
- c- Same effect if given in the appropriate dose.
- d- Differ in shape.
Captopril is a first-generation angiotensin-converting enzyme (ACE) inhibitor, while most other ACE inhibitors are second-generation. This means that captopril was the first ACE inhibitor to be developed and marketed, and other ACE inhibitors have been developed since then with the goal of improving on captopril's properties.
differences between captopril and ACE inhibitors:
Here are some of the key differences between captopril and other ACE inhibitors:
Onset of action:
Captopril has the fastest onset of action of all ACE inhibitors. It starts to lower blood pressure within 15 minutes of taking it, and its full effect is reached within 60 to 90 minutes. Other ACE inhibitors have a slower onset of action, ranging from 30 to 90 minutes.
Duration of action:
Captopril has the shortest duration of action of all ACE inhibitors. Its effects last for about 4 to 6 hours. Other ACE inhibitors have a longer duration of action, ranging from 6 to 24 hours.
Dosage frequency:
Captopril typically needs to be taken 2 to 3 times per day to maintain a steady blood pressure level. Other ACE inhibitors can usually be taken once a day.
Side effects:
Captopril is more likely to cause certain side effects, such as a dry cough and a loss of taste, than other ACE inhibitors. These side effects are usually mild and go away on their own after a few weeks of taking captopril.
Captopril also differs from ACE inhibitors:
In addition to these key differences, captopril also differs from other ACE inhibitors in the following ways:
Captopril is a prodrug:
This means that it is converted into its active form in the body. Other ACE inhibitors are active drugs themselves.
Captopril is a thiol-containing drug:
This means that it contains a sulfur atom. Other ACE inhibitors are not thiol-containing drugs.
Captopril is excreted mainly by the kidneys:
This means that people with kidney disease need to be careful when taking captopril. Other ACE inhibitors are excreted by both the kidneys and the liver.
Overall, captopril is a safe and effective ACE inhibitor. However, it is important to talk to your doctor about whether captopril is the right ACE inhibitor for you, especially if you have any other medical conditions.
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pharmacology