Which of the following is a dopamine antagonist?
- a- Granisetron
- b- Domperidone***
- c- Cisapride
- d- Loperamide.
The answer is b- Domperidone.
Domperidone is a dopamine antagonist that is used to treat nausea and vomiting. It works by blocking the D2 dopamine receptors in the brain. This helps to reduce the activity of the vomiting center in the brain. Domperidone is available over-the-counter in some countries, but it is a prescription medication in others.
The other options are not dopamine antagonists:
- Granisetron is a 5-HT3 serotonin receptor antagonist that is used to treat nausea and vomiting.
- Cisapride is a 5-HT4 serotonin receptor agonist that is used to treat gastroesophageal reflux disease (GERD).
- Loperamide is a µ-opioid receptor agonist that is used to treat diarrhea.
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pharmacology