Tuesday, January 9, 2024

Which one is not 5HT3 antagonist.. domperidone



Which one is not 5HT3 antagonist?

  • a- tropisetron.
  • b- ondansetron.
  • c- domperidone.
  • d- gransetron.

The correct answer is c- domperidone.

Here's why:

- Tropisetron, ondansetron, and granisetron:

are all 5HT3 receptor antagonists. These medications work by blocking the serotonin 5-HT3 receptors, which are responsible for nausea and vomiting. They are commonly used to prevent and treat nausea and vomiting associated with chemotherapy, radiation therapy, and surgery.

- Domperidone:

is a dopamine D2 receptor antagonist. It works by increasing the movement of food through the gastrointestinal tract, which can help to relieve nausea and vomiting. However, it does not directly block the 5-HT3 receptors.
Therefore, domperidone is the only option that is not a 5HT3 antagonist.