A contraindication to the antimigraine drug sumatriptan is:
- A) Hypotension
- B) Hirsuitism***
- C) Gingival hyperplasia
- D) a, b and c.
The correct answer is: B) Hirsuitism.
Here's why:
- Sumatriptan is a serotonin 5-HT1B/1D receptor agonist used to treat acute migraine headaches. It works by constricting blood vessels in the brain and reducing inflammation.
- Hirsuitism is a condition characterized by excessive hair growth in men and women on areas where hair typically doesn't grow, such as the face, chest, and back. While the exact cause of hirsuitism is unknown, it is sometimes associated with high levels of androgens (male hormones).
- Sumatriptan has been reported to cause hirsuitism as a rare side effect. This is thought to be due to its interaction with androgen receptors.
Here's why the other options are incorrect:
A) Hypotension:
While sumatriptan can cause mild drops in blood pressure, it is not a contraindication for its use.
C) Gingival hyperplasia:
This is an overgrowth of gum tissue, which is not a known side effect of sumatriptan.
D) a, b and c:
Only hirsuitism is listed as a contraindication to sumatriptan.
Therefore, the only contraindication among the listed options is hirsuitism.
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pharmac