Abstract
In seven insulin-dependent diabetic subjects the disappearance rate of 125I-labelled short-acting insulin from injection sites in the abdominal wall was 86% greater than from the leg (P less than 0.005) and 30% greater than from the arm (P less than 0.05). Absorption from the arm was 40% greater than from the leg (P less than 0.05). The postprandial rise in plasma glucose concentration varied inversely with the rate of insulin absorption and was 30 to 50 mg/dL less after abdominal than after leg injection; the glycemic response after arm injection was intermediate between that after leg and abdominal injection. These results indicate that changing the insulin injection site from the leg to the abdomen or arm accelerates the absorption of insulin and diminishes the postprandial rise in plasma glucose. Varying insulin injection sites within the same anatomic region rather than between different regions may diminish daily variations in insulin absorption and in metabolic control in insulin-dependent diabetic subjects.
Why won't my blood sugar go down after taking insulin?
If the insulin dose you take isn't enough to lower high blood sugar, your doctor may change how much you take and how you take it. For instance, they may ask you to: Increase your dose. Take a fast-acting type before meals to help with swings in blood sugar after you eat.
What happens if you take insulin too close together?
While it is normal to want to lower high blood glucose as quickly as possible, especially if you don't feel well, taking rapid-acting insulin at close intervals can result in low glucose (hypoglycemia). This is called insulin stacking, over- blousing over -correcting and it is very common.
Why is my sugar still high after taking insulin?
This may be because your pancreas is unable to produce insulin, as in type 1 diabetes. Or it may be because your body is resistant to the effects of insulin, or it doesn't make enough insulin to keep a normal glucose level, as in type 2 diabetes.
What's the sliding scale for insulin?
A sliding scale varies the dose of insulin based on blood glucose level. The higher your blood glucose the more insulin you take. The Sliding Scale method is more precise than fixed dose insulin in that it takes account of the fact that people's blood glucose is not always in the normal range before meals.
What happens if you inject insulin in the wrong place?
Always work with your doctor
Injecting insulin into muscle changes the way it's metabolized, can be more painful, and may cause more bruising. And be careful to never inject long-acting insulin into muscle, as that can ruin blood sugars and send you on a blood glucose rollercoaster for the next 24 hours.
Does injection site matter?
But why should it matter where on your body you inject? In actuality, where you inject your insulin and how often you inject it there can have some considerable impacts on the rate of insulin absorption and changes in skin texture around the injection site.
Why do you pinch skin when injecting?
The reason for pinching a skinfold prior to injecting is to ensure that the insulin is administered into the subcutaneous layer, as opposed to muscle. It is well known that insulin injected directly into muscle is absorbed more quickly, and can precipitate hypoglycaemia.
Can insulin be injected incorrectly?
In Brief Incorrect administration of insulin (e.g., too little, too much, or at wrong times) can result in transient and serious hypo- and hyperglycemia, wide glycemic excursions, and diabetic ketoacidosis.
Can I take insulin 2 hours after eating?
Research shows that the best time to take mealtime insulin is 15 to 20 minutes before you eat a meal. Taking mealtime insulin after your meals may put you at a greater risk of low blood glucose, or hypoglycemia.
Why is my body not absorbing insulin?
What Causes Insulin Resistance? It isn't clear exactly what causes insulin resistance, but a family history of type 2 diabetes, being overweight (especially around the waist), and being inactive all can raise the risk. You do not have to be overweight to have insulin resistance.
What happens if insulin is absorbed too quickly?
Excess insulin in the bloodstream causes cells in your body to absorb too much glucose (sugar) from your blood. It also causes the liver to release less glucose. These two effects together create dangerously low glucose levels in your blood. This condition is called hypoglycemia.
How often do you change insulin sites?
Injection sites should be rotated with every injection. Inject at least one finger-width away from your previous injection site and try not to use an injection site more than once every four weeks.
