Omprazole:
- a- Acts as proton pump inhibitor.
- b- Blocks the hydrogen-potassium ATP enzyme system.
- c- A & B.***
The correct answer is c- A & B.
Omeprazole is a proton pump inhibitor (PPI) that blocks the hydrogen-potassium ATPase enzyme system. This enzyme system is responsible for the final step in the production of stomach acid. By blocking this enzyme system, omeprazole effectively reduces the amount of stomach acid produced.
Here's a more detailed explanation:
Proton Pump Inhibitors (PPIs):
PPIs are a class of medications that work by inhibiting the hydrogen-potassium ATPase enzyme system. This enzyme system is located on the apical membrane of parietal cells in the stomach lining. It is responsible for the final step in the production of stomach acid, which is the conversion of hydrogen ions (H+) to hydrochloric acid (HCl).
Omeprazole:
Omeprazole is a specific type of PPI that is commonly used to treat a variety of acid-related disorders, including:
- Peptic ulcers: Ulcers are open sores that can develop in the lining of the stomach or duodenum (the first part of the small intestine).
- Gastroesophageal reflux disease (GERD): GERD is a condition in which stomach acid reflux into the esophagus, causing heartburn and other symptoms.
- Zollinger-Ellison syndrome: This is a rare condition that causes the stomach to produce excessive amounts of acid.
Mechanism of Action:
Omeprazole is a prodrug, which means that it is inactive until it is activated in the acidic environment of the stomach. Once activated, omeprazole binds to the hydrogen-potassium ATPase enzyme system and blocks its activity. This effectively prevents the production of stomach acid.
Conclusion:
Omprazole is a proton pump inhibitor that blocks the hydrogen-potassium ATPase enzyme system, thereby reducing the production of stomach acid. It is used to treat a variety of acid-related disorders, including peptic ulcers, GERD, and Zollinger-Ellison syndrome.
