Addison's disease:
Adison's disease is characterized by pigmentation spread over sun-exposed areas, emotional surfaces, places of pressure, friction, and mucous membranes due to increased secretion of pigmented circulating hormones from the pituitary gland and elevated serum levels of beta-MSH.
The nipples, genitals, mucous membranes, and conjunctiva become too pigmented.
Tinea-like lesions also occur in Addison's disease.
Pigmentation of the adesonic model may be observed in 10% of patients with Addison syndrome, which is the result of increased ACTH and beta-MSH from the pituitary gland and may result from a pituitary tumor.
After adrenalectomy, progressive hyperpigmentation may occur despite adequate hormone therapy. The Turkish saddle (Sella turcica) is only enlarged in half of these patients, with apparent hyperpigmentation in the skin and mucous membranes.
Clinical manifestations:
Hyperpigmentation of the skin and mucous membranes.
Hair is usually darker in color.
Nails sometimes show multiple pigments and vertical pigmented lines.
Very high levels of both "beta-MSH and ACTH" in serum.
Adison's disease is characterized by pigmentation spread over sun-exposed areas, emotional surfaces, places of pressure, friction, and mucous membranes due to increased secretion of pigmented circulating hormones from the pituitary gland and elevated serum levels of beta-MSH.
The nipples, genitals, mucous membranes, and conjunctiva become too pigmented.
Tinea-like lesions also occur in Addison's disease.
Pigmentation of the adesonic model may be observed in 10% of patients with Addison syndrome, which is the result of increased ACTH and beta-MSH from the pituitary gland and may result from a pituitary tumor.
After adrenalectomy, progressive hyperpigmentation may occur despite adequate hormone therapy. The Turkish saddle (Sella turcica) is only enlarged in half of these patients, with apparent hyperpigmentation in the skin and mucous membranes.
Clinical manifestations:
Hyperpigmentation of the skin and mucous membranes.
Hair is usually darker in color.
Nails sometimes show multiple pigments and vertical pigmented lines.
Very high levels of both "beta-MSH and ACTH" in serum.
