Saturday, January 13, 2024

Lichen planus in the mucous membranes.. Thinning in the granular layer. Scatter in the basal layer. Inflammatory infiltration of lymphocytes, especially under the skin

Lichen planus in the mucous membranes:

Based on the provided information, you're describing histological features consistent with lichen planus in the mucous membranes. Here's a breakdown of the key points:

Lichen planus:

This is a chronic inflammatory skin and mucous membrane disease that can affect various anatomical sites, including the oral cavity, genitalia, eyes, and esophagus.

Mucous membranes:

Lichen planus in the mucous membranes presents differently than on the skin and can be more challenging to diagnose.

Histological features:

The provided details suggest several characteristic features of lichen planus in the mucous membranes:

- Thinning in the granular layer:

This refers to the stratum granulosum, a layer of the epidermis directly above the basal layer. It's often thinned or absent in lichen planus.

- Scatter in the basal layer:

This might describe lymphocytes scattered within the basal layer of the epithelium, a characteristic finding in lichen planus.

- Inflammatory infiltration of lymphocytes:

Lichen planus is characterized by a dense, band-like inflammatory infiltrate of lymphocytes in the upper dermis, sometimes extending into the epidermis.

Location of the infiltrate:

While "under the skin" is more typical for cutaneous lichen planus, infiltrates can also be seen in the submucosal connective tissue beneath the epithelium in mucous membrane involvement.

Additional Information:

Further information needed: For a more definitive diagnosis, additional information would be helpful, such as:

- Site of involvement:

Which specific mucous membrane is affected? Different locations can have slightly different presentations.
Clinical presentation: What are the patient's symptoms and what does the affected area look like?

- Other histological findings:

Are there any other specific features present in the biopsy?

- Disclaimer:

It's important to remember that I am not a medical professional and this information should not be considered a substitute for professional medical advice. Always consult a qualified healthcare provider for diagnosis and treatment of any medical condition.