The largest group is used to relieve pain and inflammation in RA NSAID S . These drugs have replaced the use of high doses of aspirin because they are less toxic and longer effect. Although the drugs NSAID S Different structure but having the same pharmacological properties where they are all heatsinks and anti-inflammatory pain relievers, where they essentially have all the same pharmacological effects but only exception to this rule is Alrovksoxab ROFECOXIB And also Silisoxab Celecoxib Both Cox-2 NSAIDs Since no two anti-platelet effect, as the short-term treatment with these drugs do not inhibit platelet aggregation as it does not prolong bleeding time.
The patient's response to NSAID S Changes dramatically as the treatment of more than one NSAID S Sometimes be necessary in order to know the best medicine. It is estimated that approximately 60% of patients will respond to any one of the NSAID S In the case of non-response should be tried several other drugs of NSAID S Even access to the best medicine. Patients are advised to change the medication after one week in the event of failure to respond to him in case the purpose of medicine is to relieve pain. As in the case of the fact that the anti-inflammatory effect is desired, the drug be given a chance 3 weeks and then change in the event of non-response. About 15% of patients will not respond to any individual NSAIDS . This big change to respond due to the mechanism of the effect of each drug mainly in addition to several other factors.
The anti-inflammatory Alsteroida qualitative proportional to effectiveness, toxicity, drug escort, the case of concurrent diseases, the patient's age, renal function and repeat dosage.
There is no evidence Synergies or reduce the toxicity of using more than one anti-inflammatory Alsteroida. In fact there is evidence that the use of antibiotics two inflammatory Alsteroidah could increase the risk of gastrointestinal toxicity.
Only one factor should be prescribed at the same time despite the fact that a short-term medication can be used in the daytime with a longer term lotion at night.
Possible to divide anti-inflammatory non Steroidah total to long or short half-life dynamic in plasma. It is assumed that effect of NSAIDs Exist in a vacuum hinge, and therefore, the pharmacokinetics in interstitial fluid can be of greater importance than those plasma pharmacokinetics. However in the interstitial fluid concentration of prostaglandins disincentive and for a long time and even when it becomes the NSAID Undetectable. Studies have demonstrated the interstitial fluid That the concentration of the drug is more potent and shown to be less volatile than in plasma concentrations. This means that a lot of NSAIDs Short-lived bio should be given only twice a day to relieve pain and stiffness. While most NSAIDs Long bio-old need for a long time to reach equilibrium and remain for a long time in the interstitial fluid after treatment interruption.
