Physiological disease rheumatoid arthritis.. A large leak of inflammatory cells into the joint. Incite synovial cells to secrete enzymes hydrolyzed protein

RA disease characterized by Leak a wide range of inflammatory cells into the joint where the synovial membrane becomes influential high leading to a doubling of Fabiroblas as synovial inflammatory cells produce very large amounts of cytokines. The latter stimulates the synovial cells to secrete enzymes hydrolyzed protein and thus be the final outcome of this process is the destruction of bone and cartilage.Current studies suggest that chronic inflammation begins Counter urges activation of T-lymphocytes, which accumulate within the joint. It also leads to other factors such as liberalization Mast cells and macrophages and synovial Fabiroblas All these factors lead to the production of inflammatory media such as serving as the killer of tumors (TNF ) And interleukin 1 (IL1 ).

These arguments lead to the crash by increasing joint events shattered the cells. One of these events include activation of synovial Fabiroblas and inciting production Alkolajnaaz and Almitalobrotineaz who collagen Aahtman. Some other cytokines such as IL6 The cells macrophages favorite incite other factors play a role in the cascade of inflammation. There is a scarcity of CD8 cells And suppressor T lymphocytes and natural killer cells and that their role is to turn off the immune response as there is a deficiency in the limvukin suggesting that the humoral and cellular response is complete. 

The initial antigen stimulates an immune response become abnormal later autoimmune eternal continue even after the elimination of the antigen. The long-term inflammation leads to excessive growth and increase the size of synovial cells, which is spread on the surface of the joint leading to the erosion of bone and cartilage. The permanent presence of inflammation of the synovial membrane leads to osmosis synovial fluid rich in protein and inflammatory cells. The articulated overseas symptoms may be a result of the systemic circulation of these immune complexes.